Hi Will,
there are three things you have to check out for adressing a Synth:
- the Zaquencer track you´re planning to use must be unmuted: Mixer Menu->Track Buttons 1-4 toggle mutes (Track 1 is unmuted as default, the others are muted)
- in the Global Menu, the Midi Out A/B of the track has to correspond to the Midi Out port where the Synth is connected
- in the Global Menu, the Midi Out Channel of the track has to be set to match the Synth´s Midi Channel
That should do it. Please try these steps and let me know if you have more specific questions.
Did you have success using one single Synth yet?